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Filtered Search Results
Ambeed AMBEED
5000882873 FMOC-VAL-ALA-OH 10G
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Ambeed AMBEED
5000883230 FMOC-VAL-OH 100G
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Medchemexpress LLC Azido-peg3-val-cit-pab-pnp | 2055047-18-0 | MFCD30527416 | 99.1% | 773.79 | C34H47N9O12 | 10 MG
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Azido-PEG3-Val-Cit-PAB-PNP is a cleavable three-unit PEG linker bearing an azide functional group, designed for use in bioconjugation and the synthesis of antibody-drug conjugates and PROTACs. It contains a protease-cleavable Val-Cit dipeptide and a para-aminobenzyl spacer with a PNP leaving group, enabling enzymatic payload release and click-based conjugation.
- Cleavable Val-Cit-PAB motif for enzyme-triggered payload release.
- Azide functional group compatible with CuAAC and SPAAC click reactions.
- Three-unit PEG spacer improves solubility and flexibility in conjugates.
- Available in small laboratory quantities for synthetic applications.
- High reported purity suitable for bioconjugation workflows.
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Medchemexpress LLC Acetylene-linker-Val-Cit-PABC-MMAE | 1411977-95-1 | 95.2% | 1307.62 g/mol | C67H106N10O16 | 10 MG
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Acetylene-linker-Val-Cit-PABC-MMAE is an antibody-drug conjugate (ADC) linker-payload conjugate that couples an alkyne-bearing cleavable Val-Cit-PABC linker to the tubulin inhibitor MMAE. The acetylene handle enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation, while the Val-Cit-PABC motif permits proteolytic release of the payload after internalization.
- Contains an alkyne handle for CuAAC click chemistry
- Val-Cit-PABC motif enables proteolytic release of MMAE
- Provides a cleavable linker-payload architecture for ADC development
- Molecular formula C67H106N10O16 and molecular weight 1307.62 g/mol
- Typical purity approximately 95.2%
- Supplied as a 10 mg sample; store at 4°C under inert atmosphere
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Medchemexpress LLC Maleimide-PEG8-Val-Ala-PABC | 99.1% | 867.98 g/mol | C41H65N5O15 | 50 MG
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Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine-type antibody-drug conjugate (ADC) linker containing a maleimide reactive group, a PEG8 spacer, and a Val-Ala dipeptide PABC self-immolative spacer. It is designed for thiol conjugation to antibodies and protease-triggered release of payloads in ADC applications.
- Cleavable by cathepsin B and related proteases.
- Maleimide group enables thiol conjugation to biomolecules.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity: 99.1%.
- Viscous liquid, colorless to light pink.
- Storage: keep sealed at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC Mal-amide-PEG8-Val-Ala-PAB-PNP | 2210247-59-7 | 95.7% | 1033.08 | C48H68N6O19 | 25 MG
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Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads to antibodies and enable enzymatic release inside target cells. It combines a maleimide reactive group, a PEG8 spacer, a Val-Ala protease-cleavable dipeptide, a para-aminobenzyl self-immolative spacer, and a p-nitrophenyl carbonate leaving group.
- Cleavable by proteases to enable intracellular payload release.
- Maleimide group enables thiol conjugation to antibody cysteines.
- PEG8 spacer improves solubility and linker flexibility.
- High purity suitable for research bioconjugation (~95.7%).
- Available in small mg-scale packs for laboratory conjugation workflows.
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Medchemexpress LLC Fmoc-val-cit-pab-duocarmycin | 99.4% | 1050.59 g·mol⁻¹ | C58H60ClN7O10 | 1 MG
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Fmoc-Val-Cit-PAB-Duocarmycin is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) research. It couples a Duocarmycin payload to an Fmoc-Val-Cit-PAB cleavable linker, and is supplied as a solid with reported high purity and defined storage conditions.
- High purity (99.44%).
- Molecular weight 1050.59 g·mol⁻¹.
- Molecular formula C58H60ClN7O10.
- Solid form, white to yellow.
- Storage: powder -20 °C; in solvent -80 °C for 6 months or -20 °C for 1 month.
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Medchemexpress LLC Bi-mc-vc-pab-mmae | 1620837-70-8 | 98.4% | 1413.66 | C71H104N12O18 | 5 MG
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Bi-Mc-VC-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugate (ADC) research. It links a Bi-Mc-Val-Cit-PAB cleavable linker to the tubulin inhibitor monomethyl auristatin E (MMAE) and is supplied for preclinical ADC construction and linker evaluation. Reported purity is 98.43%; molecular formula C71H104N12O18; molecular weight 1413.66 g/mol. Store at -20°C, protected from light, under nitrogen.
- Drug-linker conjugate for ADC research
- Cleavable Val-Cit-PAB linker coupled to MMAE
- Purity 98.4% as reported
- Molecular formula C71H104N12O18; molecular weight 1413.66 g/mol
- Store at -20°C, protected from light, under nitrogen
- Supplied as a solid in small research quantities (5 MG shown)
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Medchemexpress LLC Fmoc-val-ala-aminomethyl acetate | 2505045-86-1 | 97.3% | 481.54 | C26H31N3O6 | 1 G
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Fmoc-Val-Ala-aminomethyl acetate is a valine-alanine protease-cleavable linker reagent used in the synthesis of antibody-drug conjugates (ADCs) for research applications. It is characterized by LCMS-reported purity and is used to introduce a cleavable spacer between antibody and payload in linker-drug constructs.
- Protease-cleavable valine-alanine linker.
- Suitable for ADC synthesis and linker-drug conjugation.
- Purity 97.3% (LCMS).
- Molecular weight 481.54 g/mol.
- Molecular formula C26H31N3O6.
- Supplied as a 1 G pack for research use.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000745968 POLY-D-LYSINE HYDROB 50MG
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Ambeed AMBEED
5000869441 IVDDE-LYSFMOC-OH 1GR
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Ambeed AMBEED
5000870658 IVDDE-LYSFMOC-OH 250MG
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Chemscene CHEMSCENE
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5000577012 FMOC-LYS AC -OH 10G
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Chemscene CHEMSCENE
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5000577400 FMOC-LYS MTT-OH 1G
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Medchemexpress LLC Z-D-Chg-OH 25g | 25G
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Z-D-Chg-OH 25g | 25G
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